This article examines the use of bone dowels in the stone assemblages of Notre-Dame de Senlis cathedral. The method consists of inserting a piece of bone into a cavity between two blocks, similar to the use of tenon and mortise. The method identified concerns several elements of the building, notably the spire, pinnacles, flying buttresses and a column shaft. The study is based on an interdisciplinary approach combining art history, architecture, archaeozoology, proteomics and radiocarbon dating. Morphological examination indicates a selection of mostly caprine metapods, whose elongated and compact shape lends itself to use as dowels. Proteomic analysis confirms the predominance of domestic sheep (Ovis aries), with only one sample attributed to domestic cattle (Bos taurus). Radiocarbon dates place the analysed bones between the second half of the 17th century and the first half of the 20th century. This discrepancy with the stylistic chronology of the blocks relate the dowels studied to restoration rather than to the initial use of the stone. Archive sources also confirm the use of this technique in Senlis in the years 1830-1835. The study thus invites us to distinguish the age of the blocks, the age of the bone material, and the time of its insertion into the stone. It shows that bone, a discrete material in written sources, was able to meet precise technical constraints in the fixation of monumental microarchitecture. Finally, it paves the way for a broader rereading of the uses of animal materials in construction and restoration projects.