Since the twentieth century, in the region of Île-de-France and Centre-Val de Loire (France), the first geologic and prehistoric research allowed to collect Pleistocene large mammal bones in quaternary sedimentary deposits, notably in valley and caves. Despite some stratigraphic and chronological gaps, they spotlight an important data potential to explore or to review. Today, rescue archaeology allow to explore various sedimentary field (fluvial alluvium, slope deposit, silt on plateau, etc.), by covering usually large area. The multiplication of evaluation and excavation, particularly in Île-de-France, allowed recent discovery of bone remains, associated with lithic industries, well dated during middle and upper Pleistocene. After a brief state of knowledge about old discoveries of faunal remains in these region, covering the Center and the South-West of the Paris basin, the recent discoveries will be presented, allowing discussion about their contribution to biochronological data in a larger geographical scale, and also, to the potential paleontological context.